Molecular Characteristics of Mammalian Dopamine Receptors
نویسندگان
چکیده
منابع مشابه
Molecular diversity of the dopamine receptors.
Our current understanding of the relationship between the dopaminergic system and human brain disorders is based on two fundamental discoveries: dopamine-replacement herapy can alleviate Parkinson’s disease (1-3) and, secondly, many antipsychotic drugs are dopamine receptor antagonists (4-7). These discoveries have guided two major directions in dopamine-related basic research and drug design: ...
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Three-dimensional computer models of the rat D2, D3 and D4 dopamine receptor subtypes have been constructed based on the diffraction co-ordinates for bacteriorhodopsin, another membrane-bound protein containing seven transmembrane domains presumed to be arranged in a similar spatial orientation. Models were assembled by aligning the putative transmembrane domains of the dopamine receptors with ...
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m: Dopsmine (D.4) is a major neueotrsnsmitter in the retins. It is synthesized in smacrfne and interplexiform cells projecting t” both the inner (IPL) and outer (OPL) plexiform 1srers. DAer,,ic actions are known to occur through Dl vs DZ receptors. and there is evidence that DA can set at-synaptic ~8 non synaptic sites. so. it “SE imports”t to 1ocslire the t10 receptortypes in the adult end -de...
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This article has no abstract
متن کاملPutative Binding Sites of Dopamine and Arachidonoyl Dopamine to Beta-lactoglobulin: A Molecular Docking and Molecular Dynamics Study
Because of participation in many aspects of human life, and due to oxidation-sensitive characteristics of dopamine (DA) and arachidonoyl dopamine (AA-DA), the necessity of biocompatible carrier to keep them against oxidation is of importance. In this work, we explored the putative binding sites of DA and AA-DA to -lactoglobulin (BLG) as potent carrier. Docking results identified the binding si...
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ژورنال
عنوان ژورنال: Pharmacology & Toxicology
سال: 1997
ISSN: 0901-9928,1600-0773
DOI: 10.1111/j.1600-0773.1997.tb00039.x